Español
4',5,7-TRIMETHOXYFLAVONE /Apigenin Trimethyl Ether 98% | CAS 5631-70-9 | Natural Flavonoid Supplier
Apigenin Trimethyl Ether (CAS: 5631-70-9) is a naturally derived methoxyflavone with ≥98% purity, validated by HPLC. Known for its anti-inflammatory, antioxidant, and neuroprotective properties, it is widely applied in nutraceuticals, functional foods, and cosmeceuticals.
Purity: ≥98% (HPLC verified)
Appearance: Yellow to off-white crystalline powder
Functions: NF-κB & COX-2 inhibition, ROS reduction, neuroprotection, anti-aging support
Applications: Nutritional supplements, fortified beverages, anti-aging skincare formulations
Packaging: 100 g / 1 kg / 5 kg with long-term stability under -20°C
Nanjing Spring & Autumn Biological Engineering Co., Ltd. is a trusted manufacturer and global supplier of high-quality flavonoid ingredients. We provide stable supply, competitive pricing, and technical support for research and industrial applications.
Nombre del producto :
4',5,7-TRIMETHOXYFLAVONE /Apigenin Trimethyl EtherN.º CAS :
5631-70-9Apariencia :
Yellow to off-white crystalline powderEspecificación :
98%CAS: 5631-70-9
Molecular Formula: C₁₈H₁₆O₅
Molecular Weight: 312.32 g/mol
Appearance: Yellow crystalline to off-white powder
Multi-Pathway Anti-Inflammatory & Antioxidant Agent
≥98% Purity (HPLC-UV validated, λmax 332 nm)
Anti-Inflammatory Modulator: Suppresses NF-κB signaling and downregulates COX-2 expression.
Antioxidant Protector: Inhibits ROS generation and enhances cellular redox defense.
Cytoprotective Role: Shields neurons and endothelial cells from oxidative stress-induced apoptosis.
Cytokine Regulation: Reduces TNF-α (↓72%) and IL-1β (↓65%) in activated macrophages.
Enzyme Inhibition: Inhibits COX-2 (IC₅₀: 18 μM) and iNOS expression (↓55%).
ROS Suppression: Decreases intracellular ROS by 68% at 20 μM.
Enzyme Induction: Activates Nrf2/HO-1 pathway, enhancing antioxidant enzyme activity (2.6× vs. control).
Neuroprotection: Prevents Aβ-induced neurotoxicity (cell viability ↑45%).
Vascular Health: Improves endothelial nitric oxide production (↑38%) and reduces lipid peroxidation.
Apoptosis Induction: Upregulates Bax/Bcl-2 ratio in cancer cell lines.
Cell Cycle Arrest: Inhibits proliferation via G2/M checkpoint modulation.
*For research purposes only, not for therapeutic claims.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD, C18 reverse phase) |
| Source | Plant-derived flavonoid |
| Melting Point | 187–189°C |
| Solubility | DMSO (80 mg/mL), ethanol (25 mg/mL); lipophilic |
| Storage | -20°C in amber container (36-month stability) |
| Key Impurities | ≤1.0% O-methylated flavones (HPLC controlled) |
| Certifications | ISO 9001 |
Anti-Inflammatory Complexes: 50–200 mg/day combined with quercetin or luteolin for synergistic effects.
Cognitive Support Supplements: 10–30 mg/serving in nootropic blends.
Fortified Beverages: Nanoemulsion delivery improves solubility and bioavailability (↑2.7×).
Healthy Oils: Stabilizes lipid systems with antioxidant properties.
Skin Anti-Aging Serums: 0.05–0.2% concentration reduces oxidative stress and glycation markers.
UV Protection Formulas: Acts as a natural photo-protective agent in topical creams.
High Purity: ≥98% verified by HPLC, residual solvents <10 ppm.
Stability: 24–36 months under recommended storage.
Versatility: Applicable across nutraceuticals, functional foods, and cosmeceuticals.
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 100 g | Double aluminized bags + argon | 24 months |
| 1 kg | Pharma-grade PET jars | 24 months |
| 5 kg | Vacuum-sealed stainless steel | 24 months |
Stored at -20°C, O₂ <0.1%; stability verified under ICH Q1A guidelines.
Q: How to confirm anti-inflammatory activity?
A: Batch-specific COX-2 and NF-κB inhibition assay data available on request.
Q: Solubility solutions for formulation?
A: Phospholipid complexes and MCT oil carriers enhance bioavailability.
Q: Can it be used in skincare formulations?
A: Yes, validated stability in emulsions and serums at 0.05–0.2% concentration.
ciclopamina 98% (CAS: 4449-51-8), un potente alcaloide esteroide que se dirige a la vía Hedgehog, inhibe selectivamente Smoothened (Smo) con IC50 de 46 nM. Este inhibidor de grado farmacéutico está validado para investigación oncológica (carcinoma de páncreas/células basales) y estudios de diferenciación de células madre.
LEER MÁS
Ingenol es un intermedio farmacéutico de alta pureza derivado de fuentes vegetales naturales. Nuestro producto garantiza una pureza superior al 99 % y un riguroso control de calidad, lo que garantiza la fiabilidad para las necesidades de investigación y producción. Con precios competitivos y una logística global flexible, ofrecemos un soporte integral en la cadena de suministro para satisfacer las diversas demandas de nuestros clientes.
LEER MÁS
Un triterpenoide pentacíclico de origen natural, Lupeol Se extrae de fuentes vegetales como fresas, mangos y hierbas tradicionales. Con más del 99% de pureza HPLC, nuestro Lupeol cumple rigurosos estándares farmacéuticos para investigación y producción.
LEER MÁS
curculigosido Es un glucósido fenólico de alta pureza aislado de la especie Curculigo, ampliamente utilizado en la investigación farmacológica por sus potentes bioactividades. Con una pureza ≥98% confirmada por HPLC, este compuesto sirve como estándar de referencia crucial en el descubrimiento de fármacos y estudios mecanísticos.
LEER MÁS
Forbol 12-Miristato 13-Acetato (PMA) 98% (CAS:16561-29-8) es un activador de PKC cristalino ultrapuro derivado de semillas de Croton tiglium, validado para la promoción tumoral y la investigación inmunológica. Con una pureza ≥98% verificada por HPLC, induce de forma fiable las vías dependientes de PKC a concentraciones de 1-100 nM en modelos que abarcan desde la carcinogénesis iniciada por DMBA hasta estudios de NETosis de neutrófilos.
LEER MÁS
Red IPv6 compatible
