Croceic Acid (Crocetin) CAS 27876 - 94 - 4: A Multifunctional Carotenoid for Cosmeceutical Health

🌿 Croceic Acid (Crocetin)

CAS No.: 27876-94-4
Molecular Formula: C₂₀H₂₄O₄
Molecular Weight: 328.40 g/mol
Appearance: Brick-red orthorhombic crystals
Source: Crocus sativus L. (saffron stigma), Gardenia jasminoides fruits

⚡️ Core Value Proposition

Multifunctional Carotenoid for Metabolic & Cellular Health

• ≥99% Purity (HPLC-validated): Batch-to-batch consistency ensured.

• Bile Metabolism Regulator: Reduces bilirubin by 52% in bile duct-ligated rabbits (dose-dependent).

• Antiatherogenic Activity: 63% decrease in aortic plaques in cholesterol-fed rabbit models.

✅ Biologically Validated Functions

1. Hepatoprotection & Metabolic Health

   • NAFLD/Fatty Liver Support: 100 mg/kg/day reduces liver triglycerides by 48% via AMPK activation.

   • Cholesterol Management: Inhibits arterial plaque formation in hypercholesterolemic models.

2. Oncological Applications

   • Antitumor Activity: Synergizes with chemotherapy agents (e.g., doxorubicin), inducing apoptosis via Bax/Bcl-2 pathway.

3. Cosmeceutical Benefits

   • UV Protection: Topical 1-3% formulations inhibit MMP-1 (82%) and prevent collagen degradation.

⚙️ Technical Specifications

🧪 Applications

1. Nutraceuticals & Pharmaceuticals

• Liver Health Formulations: 50–100 mg capsules for NAFLD/cholesterol management.

• Oncology Adjuvants: Enhances chemo efficacy while reducing toxicity (10–25 mg/kg doses).

2. Functional Foods

• Natural Colorant: Approved for beverages/baked goods (pH-stable in alkaline emulsions).

3. Cosmeceuticals

• Anti-Aging Serums: 1–3% concentrations in PEG-400 bases for topical delivery.

🚀 Competitive Advantages

1. Green Extraction Technology

• Solvent-free, yield ≥96%, energy-efficient vs. solvent methods.

2. Global Compliance Ready

• Heavy metals controlled (As <0.1 ppm, Pb <0.2 ppm; ICP-MS).

3. Polymorph Stability

• Orthorhombic crystals maintain integrity at ≤140°C (ideal for tablet compression).

📦 Industrial Packaging

⚠️ Safety & Toxicology

• Acute Toxicity: LD₅₀ (oral, rat) >5,000 mg/kg; non-genotoxic.

• Allergen-Free: Certified gluten/dairy/nut-free.

❓ Critical FAQs

Q1: How to verify antitumor activity in batches?
→ Batch-specific apoptosis assay reports (HL-60/SMMC-7721 cells) included.

Q2: Solubility for injectable formulations?
→ Use pyridine-based carriers (solubility ↑ to 50 mg/mL).

Q3: Stability in high-pH functional foods?
→ Stable at pH 8–10 with 0.1% ascorbyl palmitate antioxidant.