High-Purity Tangeretin 98% | CAS 481-53-8 | Citrus PMF Extract Supplier

🌿 Tangeretin (Citrus Polymethoxyflavone)
CAS No.: 481-53-8
Molecular Formula: C₂₀H₂₀O₇
Molecular Weight: 372.37 g/mol
Appearance: White to off-white crystalline powder
Source: Citrus reticulata peel (mandarin orange), Citrus aurantium (bitter orange)

⚡️ Core Value Proposition

Multi-Target Metabolic Regulator & Neuroprotector

• ≥98% Purity (HPLC-validated), ensuring batch-to-batch consistency and bioactivity.

• Anticancer Activity: Inhibits proliferation of liver cancer SMMC and leukemia HL cells (IC₅₀: 15 μM) with no toxicity to normal immune cells.

• Neuroprotection: Suppresses Notch signaling, reducing neuroinflammation and Aβ aggregation—potential for Alzheimer’s therapy.

✅ Biologically Validated Functions

1. Antitumor & Immunomodulation

   • Induces apoptosis in cancer cells via Bax/Bcl-pathway activation and caspase cleavage.

   • Inhibits histamine release from basophils, alleviating allergic responses6.

2. Anti-Inflammatory & Smooth Muscle Relaxation

   • Reduces airway spasms by suppressing smooth muscle hypercontraction.

   • Antifungal activity against skin pathogens (e.g., Trichophyton mentagrophytes).

3. Cardiovascular Protection

   • Lowers thrombosis risk and improves microcirculation.

⚙️ Technical Specifications

🧪 Applications

1. Pharmaceuticals & Nutraceuticals

• Oncology Adjuvants: Synergizes with chemotherapy (e.g., doxorubicin), reducing side effects while enhancing efficacy.

• Liver Health Formulations: 10–50 mg/dose in hepatoprotective blends (lowers ALT by 48% in NAFLD models).

2. Cosmeceuticals

• Anti-Aging Serums (1–3%): Inhibits MMP-1 (82%) and UV-induced collagen degradation.

3. Functional Foods

• Stabilized Beverages: β-cyclodextrin inclusion complexes boost water solubility to 35 mg/mL for clear drinks (shelf-life >18 months).

🚀 Competitive Advantages

1. Green Extraction Technology

• Supercritical CO₂ Extraction: Solvent-free, yield ≥96%, energy-efficient (40% less vs. ethanol methods).

2. Polymorph Control

• Needle Crystals (β-form): Optimized bioavailability (particle size: 100–300 μm) and bulk density (0.45 g/cm³) for tablet compression.

3. Global Compliance

• Dossiers prepared for ISO9001 registrations; heavy metals controlled (As <0.1 ppm, Pb <0.2 ppm; ICP-MS).

📦 Industrial Packaging

⚠️ Safety & Toxicology

• Acute Toxicity: LD₅₀ (oral, rat) >1,000 mg/kg; non-genotoxic (OECD 471 compliant).

• Handling: Use PPE (gloves, goggles); avoid dust inhalation.

❓ Critical FAQs

Q1: How to confirm antitumor activity in batches?
→ Batch-specific cytotoxicity reports (e.g., HL-60 cell inhibition) included.

Q2: Solubility for topical formulations?
→ Use PEG-400 as carrier (solubility ↑ to 50 mg/mL).

Q3: Stability in high-pH products?
→ Stable at pH 3–7; add 0.1% ascorbyl palmitate for alkaline formulations.