Nobiletin 98% Powder | CAS 478-01-3 | Metabolic & Nootropic Enhancer

Nobiletin (Citrus Flavonoid) 98%
CAS: 478-01-3
Molecular Formula: C₂₁H₂₂O₈
Molecular Weight: 402.39 g/mol
Appearance: Bright yellow crystalline to Off-white powder

Core Value Proposition
Multi-Target Metabolic & Cognitive Enhancer
≥98% Purity (HPLC-UV validated, λmax 330 nm)
• AMPK Activator: Enhances glucose uptake (2.8× GLUT4 translocation at 20 μM).
• Neuroprotectant: Inhibits Aβ40 aggregation (IC₅₀: 15 μM) and reduces tau phosphorylation.

Biologically Validated Functions
1. Metabolic Health
• Glucose Control: 100 mg/kg/day reduces fasting glucose by 31% in diabetic models.
• Lipid Modulation: Downregulates SREBP-1c (↓45%) and FAS (↓52%) at 50 μM.

2. Neurocognitive Benefits
• Memory Enhancement: 10 mg/kg improves Morris water maze performance by 40%.
• Neuroinhibition Control: Suppresses TNF-α (↓78%) and IL-6 (↓69%) in microglia.

3. Longevity & Anti-Aging
• Mitochondrial Biogenesis: Induces PGC-1α expression (3.5× vs. control).
• Senolysis: Reduces SA-β-gal+ cells by 60% at 30 μM (senescent fibroblasts).

Technical Specifications

 Research & Industrial Applications
Nutraceutical Formulations
• Metabolic Syndrome Capsules: 50-200 mg with hesperidin (synergy ratio 1.6).
• Nootropic Stacks: 10 mg/serving in cognitive supplements (validated in RCTs).

Functional Foods
• Fortified Beverages: 0.05% nanoemulsion improves bioavailability 3.2×.
• Healthy Oils: Oil-soluble forms (5-50 ppm) extend oxidative stability.

Cosmeceutical Innovations
• Anti-Glycation Serums: 0.1-0.5% inhibits AGEs formation by 88%.

Competitive Advantages

• Purity: 98.5% with residual solvents <10 ppm
• Yield efficiency: 30% higher vs. ethanol extraction

• Platelet Crystals (β-form):

• Particle size: 20-80 μm

• Bulk density: 0.68 g/cm³

• Flowability: Carr index 12

Industrial Packaging

*At -20°C, O₂ <0.1%; ICH Q1A stability verified

Critical FAQs
Q: How to verify AMPK activation?
A: Batch-specific Western blot reports (p-AMPK/AMPK ratio) included.

Q: Solubility for softgel encapsulation?
A: Use MCT oil carriers (solubility ↑ to 80 mg/mL) or phospholipid complexes.

Q: Stability in liquid formulations?
A: Maintains >90% potency with 0.1% ascorbyl palmitate + nitrogen flushing.